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DON Contributes to Clostridial Enterotoxemia


It is possible to reproduce necrotic enteritis under controlled laboratory conditions by administering a toxigenic strain of Clostridium perfringens to broiler chickens.  Investigation of causal factors shows that the occurrence of acute clostridial necrotic enteritis and more moderate ulcerative enteritis is associated with nutritional and environmental factors.  Starvation, sudden changes in diet composition or physical form, wet litter and mild coccidiosis have been shown to precipitate outbreaks of enterotoxemia in commercial flocks.