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Mechanism Defined for Beneficial Effect of Probiotics


Studies conducted at Washington University School of Medicine in St. Louis demonstrated that specific probiotic organisms and components of the biome are capable of degrading potentially harmful compounds.

The Maillard Reaction results in the formation of compounds comprising amino acids and sugars. Fructoselysine, results from a Maillard Reaction and is implicated in the occurrence of cardiovascular conditions including atherosclerosis and also metabolic dysfunctions including diabetes.

Using a mouse model, the Washington University school demonstrated that Collinsella intestinalis, an organism in the intestinal microbiome was capable of degrading fructoselysine into innocuous byproducts.

Although the studies were directed at human disease, it is possible that probiotic organisms are capable of similar action in the intestinal tract of monogastric livestock. Identifying these species and their inclusion in commercial probiotic additives could enhance the beneficial effects of existing combinations.

*Wolf, A. R. et. al., Bioremediation of a common product of food processing by a human gut bacterium. Cell Host and Microbe. 26:463-477 (2019)