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Purina Prebiotic and Probiotic Combination Suppresses SE


Published research by scientists at the Purina Animal Nutrition Research Laboratory in combination with university and private test facilities demonstrated the benefits of a combination of probiotics and prebiotics (Fulfill® Plus) to suppress Salmonella Enteritidis (SE) infection in both pullets and laying hens.


In the first of a series of trials1, cage-housed day-old pullets were challenged with 1.8x109 CFU on day 21 as a positive control.  The second treatment was fed the pre-and-probiotic combination at a level of 1.5 lb./ton.  Pullets were sampled for SE shedding at 6, 10, 14 and 18-days post infection.  The pre and probiotic combination numerically suppressed SE counts in the caeca by 0.5 log10 at 18 days post-infection.  Fulfill® Plus significantly reduced the number of caecal samples yielding SE compared to the untreated, positive controls.


In a subsequent trial2 to evaluate the pre and probiotic combination, Fulfill® Plus was fed to caged pullets from 10 weeks of age.  At 17 weeks, pullets were individually challenged with a dose of 3 x 106 CFU SE per bird.  The pre-and-probiotic combination was administered at week 10 and significantly reduced the level of isolation of SE from the caeca of pullets in addition to reducing recovery from ovaries over the 10 to 77 week period.


1 Kimminau, E. A. et al., Applied Research Note:  Combination of Probiotic and Prebiotic Impacts Salmonella    Enteritidis Infection in Layer Pullets, Journal of Applied Poultry Research.

2 Kimminau, E. A., Combination of Probiotic and Prebiotic Impacts Salmonella Enteritidis Infection in Layer Hens, Journal of Applied Poultry Research.